An article available online from Cell called “The Origins and Drivers of Insulin Resistance” is very technical but well worth a read. The major take-away points are that research supports 3 primary drivers of insulin resistance:
- impaired lipid metabolism
… we believe that inflammation, lipid metabolism, and the microbiota are the major interacting components [implicated in insulin resistance] and that other proposed factors ultimately work through one or more of these mechanisms.
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