breastfeeding, microbiome, stress, diabetes
“We identified dose-response associations with breastfeeding duration for IQ and educational attainment. In the confounder-adjusted analysis, participants who were breastfed for 12 months or more had higher IQ scores…, more years of education…, and higher monthly incomes… than did those who were breastfed for less than 1 month. The results of our mediation analysis suggested that IQ was responsible for 72% of the effect on income.”
“This historical example illustrates how industry protects itself from potentially damaging research, which can inform policy makers today. Industry opposition to current policy proposals—including a World Health Organization guideline on sugars proposed in 2014 and changes to the nutrition facts panel on packaged food in the US proposed in 2014 by the US Food and Drug Administration—should be carefully scrutinized to ensure that industry interests do not supersede public health goals.”
“At the age of 13 years ADHD or AS was diagnosed in 6/35 (17.1%) children in the placebo and none in the probiotic group (p=0.008)… Probiotic supplementation early in life may reduce the risk of neuropsychiatric disorder development later in childhood possible by mechanisms not limited to gut microbiota composition.”
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome (2015)
“Here we report that, in mice, relatively low concentrations of two commonly used emulsifiers, namely carboxymethylcellulose and polysorbate-80, induced low-grade inflammation and obesity/metabolic syndrome in wild-type hosts and promoted robust colitis in mice predisposed to this disorder… These results support the emerging concept that perturbed host–microbiota interactions resulting in low-grade inflammation can promote adiposity and its associated metabolic effects. Moreover, they suggest that the broad use of emulsifying agents might be contributing to an increased societal incidence of obesity/metabolic syndrome and other chronic inflammatory diseases.”
“The results obtained in this study indicate that early life (day 4 after birth) perturbations have long-lasting effects on the gut system, both in gene expression (day 55) as well as on microbiota composition (day 176)… Based on the observed difference in gene expression at day 55, it is hypothesized that due to the difference in immune programming during early life, the systems respond differently to the post-weaning newly acquired microbiota.”
Repeated stressors in adulthood increase the rate of biological ageing (2015)
“The current data demonstrate that repeated exposure to experimental stressors affects the rate of biological ageing in adult Eurasian blackbirds. Both telomeres and oxidative damage were affected by repeated stress exposure and thus can serve as blood-derived biomarkers of biological ageing.”
“We conclude that in this study antineoplastons have demonstrated a promising level of efficacy against postoperative recurrence with a median [cancer-specific survival] time of 67 months in the [antineoplastons] arm versus 39 months in the control arm, achieved via inhibition of early growth in metastatic tumors from colorectal cancer. The administration of antineoplaston AS2–1 may be clinically effective as a postoperative adjuvant therapy in liver metastasis from colorectal cancer.”
“Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone. This was associated with decreased pancreatic and liver triacylglycerol stores. The abnormalities underlying type 2 diabetes are reversible by reducing dietary energy intake.”
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies (2011)
“We only know for sure that autoimmunity is the predominant effector mechanism of T1D, but may not be its primary cause… In this comprehensive review, we explain the genetic, environmental, and immunological data underlying the prevention and intervention strategies to constrain T1D.”